Protein Details: Neuronal acetylcholine receptor subunit alpha-7
Protein ID
ICDB_Pro_0764
Protein Name
Neuronal acetylcholine receptor subunit alpha-7
Gene Name
Chrna7; Acra7
Organism
Rattus norvegicus (Rat)
Length
502 amino acids
AlphaFoldDB
AF-Q05941-F1-model_v4.pdb
Function
After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Sequence
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
PDB Structures
Ligand Binding
Binding Site
Disease
Location
At least in chromaffin cells
DOI ID
10.1111/j.1460-9568.1995.tb00668.x
RefSeq
NP_776940.1 [P54131-1]